Currently, I'm using Mozy. It simply works, and has for years for me. Handles online &amp; local backups.

If you're looking for TONS of options, check out CrashPlan: http://www.onlinebackupsreview.com/crashplan.php

It's not something I'd recommend to my mother, but if you're a geek like me, you'll enjoy the flexibility it has to offer.